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Bones
The combination of vitamins K and D has been shown to significantly increase bone mineral density (BMD) better than either alone. High-dose vitamin K has been shown to significantly reduce fractures in double-blind research of postmenopausal women with osteopenia. A review of seven controlled studies confirmed that high-dose vitamin K reduces the risk of fractures, and large amounts of vitamin K have been shown in preliminary research to correlate with greater BMD and to increase bone formation in some women. MK-7, the form of vitamin K in Vitamin K2+A+D3 has been shown to increase bone mineralization, to significantly reduce loss of BMD, improve bone strength and decrease risk of fracture in placebo-controlled research. K2 has also been shown to improve the ratio of bone formation to bone breakdown. A meta-analysis of thirteen controlled studies found that long-term high-dose vitamin K supplementation reduces bone loss.
Vitamin D has also been shown to increase bone density and to reduce hip fracture by 43-60%.